New in vitro and in vivo applications of physics and mathematics for the imaging of metabolism at the cellular, organ and organism levels will be discussed. For decades shelved as old biochemistry for undergraduates, the central position of metabolism in biology recently revived. Metabolism is central in brain activity and firing of neurons; in heart and muscle physiology; cancer is a metabolic glutton; accumulation of metabolic waste leads to atheroma; and diabetes, obesity and other metabolic disorders are the plague of modern medicine. Novel metabolites emerge in oncology as drivers of disease; while our microbiome as well as pathogens exert some of their beneficial and detrimental effects via their own unique metabolism. Non-invasive imaging is now crossed with high throughput metabolomics and mathematical analysis of metabolic pathways to produce game-changing concepts in physiology and physiopathology.
Standing committee:
Committee 2018:
Since 2007 the overall concept of TOPIM has been that experienced, high-level international scientists and younger/less experienced scientists from diverse disciplines are spending one week together at an inspiring place and to provide a "think tank" for knowledge exchange and intensive discussion.
Presentations are held during the morning and early evening; so that there are plenty of opportunities for continued scientific discussions.
Asaph Aharoni - Rehovot, Israel
Martial Balland - Grenoble, France
Robert Gillies - Tampa, USA
Xavier Golay - London, UK
Martin Gotthardt - Nijmegen, The Netherlands
Anke Henning - Tübingen, Germany
Craig Malloy - UT Southwestern, USA
Guillem Pratx - Stanford, USA
Sabrina Ronen - University of California, USA
Matthew Vander Heiden - MIT, USA
Tim Witney - London, UK
Albert D. Windhorst - Amsterdam, The Netherlands
Mario Amend Tubingen
Annasofia Anemone Torino
Karlas Angelos Neuherberg
Robert Bielik Cambridge
Marti Boss Nijmegen
Arnaud Comment Lausanne
Eleni Demetriou London
Caterina Facchin Paris
Bénédicte Jordan Brussels
Marcel Krueger Tubingen
Rosa Maria Moresco Segrate
Marie-Aline Neveu Tubingen
Tom Peeters Nijmegen
Luka Rejc San Sebastian
Sima Stroganov Rehovot
Thomas Viel Paris
Evita Wiegers Nijmegen